The PDR or Physicians' Desk Reference is published yearly and is distributed to American Physicians and Pharmacists. Although Immunocal is a natural, non-drug supplement, it has appeared in the PDR every year since 2001. We are honored to appear in this prestigious publication.
IMMUNOCAL® is a specially formulated undenatured whey protein isolate. It holds several patents in the USA and worldwide and is listed by the FDA in the category of GRAS (generally recognized as safe). It assists the body in maintaining optimal concentrations of glutathione (GSH) by supplying the precursors required for intracellular glutathione synthesis. It is clinically proven to raise glutathione values.
Glutathione is a tripeptide made intracellularly from its constituent amino acids L-glutamate, L-cysteine and glycine. The sulfhydryl (thiol) group (SH) of cysteine is responsible for the biological activity of glutathione. Provision of this amino acid is the rate-limiting factor in glutathione synthesis by the cells since bioavailable cysteine is relatively rare in foodstuffs.
Immunocal is a bovine whey protein isolate specially prepared so as to provide a rich source of bioavailable cysteine. Immunocal can thus be viewed as a cysteine delivery system.
The disulphide bond in cystine is pepsin and trypsin resistant but may be split by heat, low pH or mechanical stress releasing free cysteine. When subject to heat or shearing forces (inherent in most extraction processes), the fragile disulfide bonds within the peptides are broken and the bioavailability of cysteine is greatly diminished.
Glutathione is a tightly regulated intracellular constituent and is limited in its production by negative feedback inhibition of its own synthesis through the enzyme gamma-glutamylcysteine synthetase, thus greatly minimizing any possibility of overdosage.
Glutathione has multiple functions:
IMMUNOCAL is a natural food supplement and as such is limited from stating medical claims per se. Statements have not been evaluated by the FDA. As such, this product is thus not intended to diagnose, cure, prevent or treat any disease.
Glutathione augmentation is a strategy developed to address states of glutathione deficiency, high oxidative stress, immune deficiency, and xenobiotic overload in which glutathione plays a part in the detoxification of the xenobiotic in question. Glutathione deficiency states include, but are not limited to: HIV/AIDS, infectious hepatitis, certain types of cancers, cataracts, Alzheimer’s Disease, Parkinsons, chronic obstructive pulmonary disease, asthma, radiation, poisoning by acetominophen and related agents, malnutritive states, arduous physical stress, aging, and has been associated with sub-optimal immune response. Many clinical pathologies are associated with oxidative stress and are elaborated upon in numerous medical references.
Low glutathione is also strongly implicated in wasting and negative nitrogen balance, notably as seen in cancer, AIDS, sepsis, trauma, burns and even athletic overtraining. Cysteine supplementation can oppose this process and in AIDS, for example, result in improved survival rates.
IMMUNOCAL is contraindicated in individuals who develop or have known hypersensitivity to specific milk proteins.
Each sachet of IMMUNOCAL contains nine grams of protein. Patients on a protein-restricted diet need to take this into account when calculating their daily protein load. Although a bovine milk derivative, IMMUNOCAL contains less than 1% lactose and therefore is generally well tolerated by lactose-intolerant individuals.
Patients undergoing immunosuppressive therapy should discuss the use of this product with their health professional. Individuals with the autosomal-recessive metabolic disorder cystinuria, are at higher risk of developing cysteine nephrolithiasis (1-2% of renal calculi).
Heating or adding IMMUNOCAL to a hot liquid, or use of a power blender to reconstitute it, will significantly decrease the effectiveness of the product.
Gastrointestinal bloating and cramps if not sufficiently rehydrated. Transient urticarial-like rash in rare individuals undergoing severe detoxification reaction. Rash abates when product intake stopped or reduced.
Maintenance dose is one sachet (10 grams) per day. For mild to moderate health challenges, 20 grams per day is recommended. Clinical trials in patients with AIDS, COPD, cancer and chronic fatigue syndrome have used 30-40 grams per day without ill effect.
IMMUNOCAL is best administered on an empty stomach or with a light meal. Concomitant intake of another high protein load may adversely affect absorption.
IMMUNOCAL is a dehydrated powdered protein isolate. It must be appropriately rehydrated before use. Ideally consumed after mixing. If it is premixed for later consumption, it should be refrigerated and consumed shortly after mixing. DO NOT heat or use a hot liquid to rehydrate the product. DO NOT use a high-speed blender for reconstitution. These methods will decrease the activity of the product.
Special low-speed blenders or mixing cups can be made available through Immunotec Inc. distribution networks.
Method 1) Pour the powder into your Immunocal mixing cup. Add 6-8 oz. of water, milk or juice. Snap lid on tightly and shake for 10-20 seconds. Let stand for 5-10 minutes. Shake again and drink.
Method 2) Pour the powder into your Immunocal blender. Add 6-8 oz. of water, milk or juice. Snap lid on tightly. Mix using short bursts of power until powder dissolved and drink.
Method 3) Pour the powder into a tall glass. Add only one tablespoon of water, milk or juice. Stir with a fork until consistency of a gravy or paste. Add 6-8 oz. more of the liquid and stir. Let stand for 5-10 minutes and drink.
Method 4) Pour the powder over apple sauce, other fruit compote, yogurt or cereal with milk. Stir until dissolved and eat.
Proper mixing is imperative. Consult instructions included in packaging.